Preparation, Characterization, and Anti-Cancer Activity of Nanostructured Lipid Carriers Containing Imatinib

Breast cancer is the most widespread malignancy in women worldwide. Nanostructured lipid carriers (NLCs) have proven effective treatment of cancer. NLCs loaded with imatinib (IMA) (NANIMA) were prepared and evaluated for their vitro efficacy MCF-7 breast cells. The hot homogenization method was used preparation NANIMAs. An aqueous solution surfactants (hot) mixed a molten mixture stearic acid sesame oil under homogenization. NANIMAs characterized size, polydispersity index, zeta potential, encapsulation efficiency, release studies, stability MTT assay (cytotoxicity studies). optimized revealed particle size 104.63 ± 9.55 d.nm, PdI 0.227 0.06, EE 99.79 0.03. All slow sustained behavior. exhibited effects on studies. cytotoxicity studies unveiled an 8.75 times increase (IC50 = 6 µM) when compared to IMA alone 52.5 In future, containing will possibly be employed cure A small amount into better than Moreover, patients likely exhibit less adverse case alone. Consequently, could prove useful treatment.